Cell atlas - ATP6V1A - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ATP6V1A
Gene description	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & vesicles. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Vesicles (supported)
Additional location	In addition localized to the Cytosol (supported)
Mouse	Localized to the Golgi apparatus, Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA035083 , HPA035084
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & vesicles. In addition localized to the cytosol.

Main location

Nucleus (supported), Vesicles (supported)

Additional location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA035083	A-431	No staining
HPA035083	U-2 OS	Nucleoplasm
HPA035083	U-2 OS	Cytosol
HPA035084	A-431	Nucleoplasm
		Vesicles
		Cytosol
HPA035084	A549	Nucleoplasm
		Vesicles
		Cytosol
HPA035084	U-2 OS	Nucleus
		Vesicles
		Cytosol

MOUSE CELLS

Main location

Golgi apparatus, Vesicles

Additional location

Nucleoplasm, Cytosol

Mouse gene

ENSMUSG00000052459 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA035084	NIH 3T3	Nucleoplasm
		Golgi apparatus
		Vesicles
		Cytosol

GENE INFORMATION
Gene name	ATP6V1A (HGNC Symbol)
Synonyms	ATP6A1, ATP6V1A1, VA68, Vma1, VPP2
Description	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A (HGNC Symbol)
Entrez gene summary	This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q13.31
Chromosome location (bp)	113747019 - 113812056
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114573 (version 83.38)
Entrez gene	523
UniProt	P38606 (UniProt - Evidence at protein level)
neXtProt	NX_P38606
Antibodypedia	ATP6V1A antibodies

PROTEIN BROWSER

ATP6V1A-001	ATP6V1A-005	ATP6V1A-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP6V1A-001 ENSP00000273398 ENST00000273398	P38606 [Direct mapping] V-type proton ATPase catalytic subunit A Show all	Enzymes ENZYME proteins Hydrolases Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005765 [lysosomal membrane] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005902 [microvillus] GO:0006810 [transport] GO:0006879 [cellular iron ion homeostasis] GO:0008286 [insulin receptor signaling pathway] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0015992 [proton transport] GO:0016324 [apical plasma membrane] GO:0016469 [proton-transporting two-sector ATPase complex] GO:0016820 [hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances] GO:0033178 [proton-transporting two-sector ATPase complex, catalytic domain] GO:0033180 [proton-transporting V-type ATPase, V1 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0043209 [myelin sheath] GO:0046034 [ATP metabolic process] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0090382 [phagosome maturation] Show all	617 aa 68.3 kDa	No	0
ATP6V1A-005 ENSP00000419294 ENST00000475322	C9JVW8 [Direct mapping] V-type proton ATPase catalytic subunit A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0015992 [proton transport] GO:0046034 [ATP metabolic process] Show all	221 aa 24.2 kDa	No	0
ATP6V1A-006 ENSP00000417545 ENST00000496747	C9JA17 [Direct mapping] V-type proton ATPase catalytic subunit A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0015992 [proton transport] GO:0046034 [ATP metabolic process] Show all	185 aa 20.2 kDa	No	0