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CSPG5

GENERAL INFORMATION

Gene name

 CSPG5

Gene description

 Chondroitin sulfate proteoglycan 5 (neuroglycan C)

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebral cortex, hypothalamus, hippocampus, cerebellum)
FANTOM5:Group enriched (caudate, brain, hippocampus, retina, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in brain.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 1 antibody.
HPA071779
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebral cortex, hypothalamus, hippocampus, cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, brain, hippocampus, retina, cerebellum)

GENE INFORMATION

Gene name

 CSPG5 (HGNC Symbol)

Synonyms

 NGC

Description

 Chondroitin sulfate proteoglycan 5 (neuroglycan C) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 47562239 - 47580792

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114646 (version 83.38)

Entrez gene

 10675

UniProt

 O95196 (UniProt - Evidence at protein level)

neXtProt

 NX_O95196

Antibodypedia

 CSPG5 antibodies

PROTEIN BROWSER
CSPG5-001
CSPG5-002
CSPG5-003
CSPG5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CSPG5-001
ENSP00000373244
ENST00000383738
O95196 [Direct mapping]
Chondroitin sulfate proteoglycan 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005796 [Golgi lumen]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0040008 [regulation of growth]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0046907 [intracellular transport]
GO:0050804 [modulation of synaptic transmission]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 566 aa
60 kDa 		Yes 1
CSPG5-002
ENSP00000264723
ENST00000264723
O95196 [Direct mapping]
Chondroitin sulfate proteoglycan 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005796 [Golgi lumen]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0040008 [regulation of growth]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0046907 [intracellular transport]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 539 aa
57 kDa 		Yes 1
CSPG5-003
ENSP00000392096
ENST00000456150
O95196 [Direct mapping]
Chondroitin sulfate proteoglycan 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0005796 [Golgi lumen]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0007399 [nervous system development]
GO:0008083 [growth factor activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030154 [cell differentiation]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0030660 [Golgi-associated vesicle membrane]
GO:0040008 [regulation of growth]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
GO:0046907 [intracellular transport]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 401 aa
43.6 kDa 		No 1
CSPG5-201
ENSP00000478923
ENST00000610462
A0A087WUT8 [Direct mapping]
Chondroitin sulfate proteoglycan 5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0016021 [integral component of membrane]
Show all
 477 aa
50.2 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.