Tissue expression of SCAP - Summary - The Human Protein Atlas

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SCAP

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SCAP
Gene description	SREBF chaperone
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA004713
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SCAP (HGNC Symbol)
Synonyms	KIAA0199
Description	SREBF chaperone (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a sterol sensing domain (SSD) and seven WD domains. In the presence of cholesterol, this protein binds to sterol regulatory element binding proteins (SREBPs) and mediates their transport from the ER to the Golgi. The SREBPs are then proteolytically cleaved and regulate sterol biosynthesis. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	47413694 - 47477126
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114650 (version 83.38)
Entrez gene	22937
UniProt	Q12770 (UniProt - Evidence at protein level)
neXtProt	NX_Q12770
Antibodypedia	SCAP antibodies

PROTEIN BROWSER

SCAP-001	SCAP-006	SCAP-007	SCAP-008	SCAP-201	SCAP-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCAP-001 ENSP00000265565 ENST00000265565	Q12770 [Direct mapping] Sterol regulatory element-binding protein cleavage-activating protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001666 [response to hypoxia] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005794 [Golgi apparatus] GO:0007568 [aging] GO:0008203 [cholesterol metabolic process] GO:0012507 [ER to Golgi transport vesicle membrane] GO:0016021 [integral component of membrane] GO:0019217 [regulation of fatty acid metabolic process] GO:0032403 [protein complex binding] GO:0032868 [response to insulin] GO:0032933 [SREBP signaling pathway] GO:0042304 [regulation of fatty acid biosynthetic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043234 [protein complex] GO:0044281 [small molecule metabolic process] GO:0045540 [regulation of cholesterol biosynthetic process] GO:0045541 [negative regulation of cholesterol biosynthetic process] GO:0045716 [positive regulation of low-density lipoprotein particle receptor biosynthetic process] GO:0051082 [unfolded protein binding] Show all	1279 aa 139.7 kDa	No	8
SCAP-006 ENSP00000415195 ENST00000448217	C9JFY0 [Direct mapping] Sterol regulatory element-binding protein cleavage-activating protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	88 aa 9.9 kDa	No	1
SCAP-007 ENSP00000408102 ENST00000416847	C9JQ35 [Direct mapping] Sterol regulatory element-binding protein cleavage-activating protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	136 aa 15.5 kDa	No	1
SCAP-008 ENSP00000423419 ENST00000495603	D6RA39 [Direct mapping] Sterol regulatory element-binding protein cleavage-activating protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	132 aa 15 kDa	No	1
SCAP-201 ENSP00000401819 ENST00000428413	F8WEH8 [Direct mapping] Sterol regulatory element-binding protein cleavage-activating protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	352 aa 38.2 kDa	No	2
SCAP-202 ENSP00000438956 ENST00000545718	A0A0A0MTG6 [Direct mapping] Sterol regulatory element-binding protein cleavage-activating protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	905 aa 97.9 kDa	No	4

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