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A majority of cancer tissues showed moderate to strong positivity. Strongest staining was observed in glandular cells in several tissues. Melanomas, endometrial, renal, urothelial and lung cancers were mainly negative.
GENE INFORMATION
Gene name
FOXP1 (HGNC Symbol)
Synonyms
12CC4, hFKH1B, HSPC215, QRF1
Description
Forkhead box P1 (HGNC Symbol)
Entrez gene summary
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0002903 [negative regulation of B cell apoptotic process] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0010595 [positive regulation of endothelial cell migration] GO:0030316 [osteoclast differentiation] GO:0032496 [response to lipopolysaccharide] GO:0032680 [regulation of tumor necrosis factor production] GO:0035926 [chemokine (C-C motif) ligand 2 secretion] GO:0036035 [osteoclast development] GO:0042116 [macrophage activation] GO:0042117 [monocyte activation] GO:0042118 [endothelial cell activation] GO:0043565 [sequence-specific DNA binding] GO:0045655 [regulation of monocyte differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050681 [androgen receptor binding] GO:0050706 [regulation of interleukin-1 beta secretion] GO:0050727 [regulation of inflammatory response] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0061470 [T follicular helper cell differentiation] GO:0072619 [interleukin-21 secretion] GO:1900424 [regulation of defense response to bacterium] GO:1901256 [regulation of macrophage colony-stimulating factor production] GO:1901509 [regulation of endothelial tube morphogenesis] GO:2001182 [regulation of interleukin-12 secretion]
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0002903 [negative regulation of B cell apoptotic process] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0010595 [positive regulation of endothelial cell migration] GO:0030316 [osteoclast differentiation] GO:0032496 [response to lipopolysaccharide] GO:0032680 [regulation of tumor necrosis factor production] GO:0035926 [chemokine (C-C motif) ligand 2 secretion] GO:0036035 [osteoclast development] GO:0042116 [macrophage activation] GO:0042117 [monocyte activation] GO:0042118 [endothelial cell activation] GO:0043565 [sequence-specific DNA binding] GO:0045655 [regulation of monocyte differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050681 [androgen receptor binding] GO:0050706 [regulation of interleukin-1 beta secretion] GO:0050727 [regulation of inflammatory response] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0061470 [T follicular helper cell differentiation] GO:0072619 [interleukin-21 secretion] GO:1900424 [regulation of defense response to bacterium] GO:1901256 [regulation of macrophage colony-stimulating factor production] GO:1901509 [regulation of endothelial tube morphogenesis] GO:2001182 [regulation of interleukin-12 secretion]
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0002903 [negative regulation of B cell apoptotic process] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0010595 [positive regulation of endothelial cell migration] GO:0030316 [osteoclast differentiation] GO:0032496 [response to lipopolysaccharide] GO:0032680 [regulation of tumor necrosis factor production] GO:0035926 [chemokine (C-C motif) ligand 2 secretion] GO:0036035 [osteoclast development] GO:0042116 [macrophage activation] GO:0042117 [monocyte activation] GO:0042118 [endothelial cell activation] GO:0043565 [sequence-specific DNA binding] GO:0045655 [regulation of monocyte differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050681 [androgen receptor binding] GO:0050706 [regulation of interleukin-1 beta secretion] GO:0050727 [regulation of inflammatory response] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0061470 [T follicular helper cell differentiation] GO:0072619 [interleukin-21 secretion] GO:1900424 [regulation of defense response to bacterium] GO:1901256 [regulation of macrophage colony-stimulating factor production] GO:1901509 [regulation of endothelial tube morphogenesis] GO:2001182 [regulation of interleukin-12 secretion]
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0002903 [negative regulation of B cell apoptotic process] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0010595 [positive regulation of endothelial cell migration] GO:0030316 [osteoclast differentiation] GO:0032496 [response to lipopolysaccharide] GO:0032680 [regulation of tumor necrosis factor production] GO:0035926 [chemokine (C-C motif) ligand 2 secretion] GO:0036035 [osteoclast development] GO:0042116 [macrophage activation] GO:0042117 [monocyte activation] GO:0042118 [endothelial cell activation] GO:0043565 [sequence-specific DNA binding] GO:0045655 [regulation of monocyte differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050681 [androgen receptor binding] GO:0050706 [regulation of interleukin-1 beta secretion] GO:0050727 [regulation of inflammatory response] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0061470 [T follicular helper cell differentiation] GO:0072619 [interleukin-21 secretion] GO:1900424 [regulation of defense response to bacterium] GO:1901256 [regulation of macrophage colony-stimulating factor production] GO:1901509 [regulation of endothelial tube morphogenesis] GO:2001182 [regulation of interleukin-12 secretion]
Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0002903 [negative regulation of B cell apoptotic process] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0010595 [positive regulation of endothelial cell migration] GO:0030316 [osteoclast differentiation] GO:0032496 [response to lipopolysaccharide] GO:0032680 [regulation of tumor necrosis factor production] GO:0035926 [chemokine (C-C motif) ligand 2 secretion] GO:0036035 [osteoclast development] GO:0042116 [macrophage activation] GO:0042117 [monocyte activation] GO:0042118 [endothelial cell activation] GO:0043565 [sequence-specific DNA binding] GO:0045655 [regulation of monocyte differentiation] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050681 [androgen receptor binding] GO:0050706 [regulation of interleukin-1 beta secretion] GO:0050727 [regulation of inflammatory response] GO:0060766 [negative regulation of androgen receptor signaling pathway] GO:0061470 [T follicular helper cell differentiation] GO:0072619 [interleukin-21 secretion] GO:1900424 [regulation of defense response to bacterium] GO:1901256 [regulation of macrophage colony-stimulating factor production] GO:1901509 [regulation of endothelial tube morphogenesis] GO:2001182 [regulation of interleukin-12 secretion]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0043565 [sequence-specific DNA binding]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0043565 [sequence-specific DNA binding]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0043565 [sequence-specific DNA binding]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis]
A0A087X2G3 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005654 [nucleoplasm] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis]
A0A087WVT2 [Direct mapping] Forkhead box protein P1
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis]
A0A0B4J2F3 [Direct mapping] Forkhead box protein P1
Show all
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0043565 [sequence-specific DNA binding]
A0A087X299 [Direct mapping] Forkhead box protein P1
Show all
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0009653 [anatomical structure morphogenesis] GO:0043565 [sequence-specific DNA binding]