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RTKN

CANCER ATLAS

Gene description

 Rhotekin

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA030259

GENE INFORMATION

Gene name

 RTKN (HGNC Symbol)

Synonyms

 B5

Description

 Rhotekin (HGNC Symbol)

Entrez gene summary

 This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p13.1

Chromosome location (bp)

 74425836 - 74442422

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114993 (version 83.38)

Entrez gene

 6242

UniProt

 Q9BST9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BST9

Antibodypedia

 RTKN antibodies

PROTEIN BROWSER
RTKN-001
RTKN-002
RTKN-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RTKN-001
ENSP00000305298
ENST00000305557
Q9BST9 [Direct mapping]
Rhotekin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0017049 [GTP-Rho binding]
GO:0034260 [negative regulation of GTPase activity]
Show all
 550 aa
61.2 kDa 		No 0
RTKN-002
ENSP00000272430
ENST00000272430
Q9BST9 [Direct mapping]
Rhotekin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0017048 [Rho GTPase binding]
GO:0017049 [GTP-Rho binding]
GO:0034260 [negative regulation of GTPase activity]
Show all
 563 aa
62.7 kDa 		No 0
RTKN-004
ENSP00000233330
ENST00000233330
Q9BST9 [Direct mapping]
Rhotekin
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005095 [GTPase inhibitor activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0017049 [GTP-Rho binding]
GO:0034260 [negative regulation of GTPase activity]
Show all
 513 aa
56.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.