Cell atlas - RTKN - The Human Protein Atlas

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RTKN

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RTKN
Gene description	Rhotekin
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Additional location	In addition localized to the Nucleoplasm (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA030259
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nucleoplasm.

Main location

Mitochondria (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA030259	A-431	Nucleoplasm
	HPA030259	A-431	Mitochondria
	HPA030259	U-2 OS	Nucleoplasm
	HPA030259	U-2 OS	Mitochondria	Intensity
	HPA030259	U-251 MG	Nucleoplasm
	HPA030259	U-251 MG	Mitochondria	Intensity

GENE INFORMATION
Gene name	RTKN (HGNC Symbol)
Synonyms	B5
Description	Rhotekin (HGNC Symbol)
Entrez gene summary	This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p13.1
Chromosome location (bp)	74425836 - 74442422
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114993 (version 83.38)
Entrez gene	6242
UniProt	Q9BST9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BST9
Antibodypedia	RTKN antibodies

PROTEIN BROWSER

RTKN-001	RTKN-002	RTKN-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RTKN-001 ENSP00000305298 ENST00000305557	Q9BST9 [Direct mapping] Rhotekin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005095 [GTPase inhibitor activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007266 [Rho protein signal transduction] GO:0017049 [GTP-Rho binding] GO:0034260 [negative regulation of GTPase activity] Show all	550 aa 61.2 kDa	No	0
RTKN-002 ENSP00000272430 ENST00000272430	Q9BST9 [Direct mapping] Rhotekin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005095 [GTPase inhibitor activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007266 [Rho protein signal transduction] GO:0017048 [Rho GTPase binding] GO:0017049 [GTP-Rho binding] GO:0034260 [negative regulation of GTPase activity] Show all	563 aa 62.7 kDa	No	0
RTKN-004 ENSP00000233330 ENST00000233330	Q9BST9 [Direct mapping] Rhotekin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005095 [GTPase inhibitor activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007266 [Rho protein signal transduction] GO:0017049 [GTP-Rho binding] GO:0034260 [negative regulation of GTPase activity] Show all	513 aa 56.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.