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KCNIP3

GENERAL INFORMATION

Gene name

 KCNIP3

Gene description

 Kv channel interacting protein 3, calsenilin

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (parathyroid gland, cerebral cortex)
GTEx:Mixed
FANTOM5:Tissue enhanced (hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Highly expressed in axonal projections in brain, and membranous expression in large intestine.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA069797
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland, cerebral cortex)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin01020304050TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin05101520RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hippocampus)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080100Tags Per Million

GENE INFORMATION

Gene name

 KCNIP3 (HGNC Symbol)

Synonyms

 calsenilin, CSEN, DREAM, KCHIP3

Description

 Kv channel interacting protein 3, calsenilin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q11.1

Chromosome location (bp)

 95297304 - 95386083

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115041 (version 83.38)

Entrez gene

 30818

UniProt

 Q9Y2W7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2W7

Antibodypedia

 KCNIP3 antibodies

PROTEIN BROWSER
KCNIP3-001
KCNIP3-004
KCNIP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNIP3-001
ENSP00000295225
ENST00000295225
Q9Y2W7 [Direct mapping]
Calsenilin
A0A024RE22 [Target identity:100%; Query identity:100%]
Kv channel interacting protein 3, calsenilin, isoform CRA_b
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Predicted intracellular proteins
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006886 [intracellular protein transport]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0019233 [sensory perception of pain]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032993 [protein-DNA complex]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0043679 [axon terminus]
GO:0044325 [ion channel binding]
GO:0048265 [response to pain]
GO:0048266 [behavioral response to pain]
GO:0048306 [calcium-dependent protein binding]
GO:0071805 [potassium ion transmembrane transport]
GO:0072659 [protein localization to plasma membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
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 256 aa
29.2 kDa 		No 0
KCNIP3-004
ENSP00000417499
ENST00000468529
Q9Y2W7 [Direct mapping]
Calsenilin
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0003677 [DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005244 [voltage-gated ion channel activity]
GO:0005267 [potassium channel activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015459 [potassium channel regulator activity]
GO:0071805 [potassium ion transmembrane transport]
GO:0072659 [protein localization to plasma membrane]
GO:1901379 [regulation of potassium ion transmembrane transport]
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 230 aa
26.3 kDa 		Yes 0
KCNIP3-201
ENSP00000354261
ENST00000360990
A0A0A0MRH3 [Direct mapping]
Calsenilin
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Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
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 256 aa
29.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.