Expression of ACTR3 in cancer - Summary

CANCER ATLAS

Gene description

ARP3 actin-related protein 3 homolog (yeast)

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Lymphoma

STAINING SUMMARY

HPA047016	HPA051683	CAB005085

GENE INFORMATION
Gene name	ACTR3 (HGNC Symbol)
Synonyms	ARP3
Description	ARP3 actin-related protein 3 homolog (yeast) (HGNC Symbol)
Entrez gene summary	The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
Chromosome	2
Cytoband	q14.1
Chromosome location (bp)	113889960 - 113962596
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115091 (version 83.38)
Entrez gene	10096
UniProt	P61158 (UniProt - Evidence at protein level)
neXtProt	NX_P61158
Antibodypedia	ACTR3 antibodies

PROTEIN BROWSER

ACTR3-001	ACTR3-003	ACTR3-004	ACTR3-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACTR3-001 ENSP00000263238 ENST00000263238	P61158 [Direct mapping] Actin-related protein 3 A0A024RAI1 [Target identity:100%; Query identity:100%] ARP3 actin-related protein 3 homolog (Yeast), isoform CRA_a Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0005885 [Arp2/3 protein complex] GO:0005903 [brush border] GO:0005911 [cell-cell junction] GO:0005925 [focal adhesion] GO:0006928 [movement of cell or subcellular component] GO:0007163 [establishment or maintenance of cell polarity] GO:0007264 [small GTPase mediated signal transduction] GO:0007411 [axon guidance] GO:0008356 [asymmetric cell division] GO:0015629 [actin cytoskeleton] GO:0016020 [membrane] GO:0016344 [meiotic chromosome movement towards spindle pole] GO:0030027 [lamellipodium] GO:0033206 [meiotic cytokinesis] GO:0034314 [Arp2/3 complex-mediated actin nucleation] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0045087 [innate immune response] GO:0048013 [ephrin receptor signaling pathway] GO:0051015 [actin filament binding] GO:0051321 [meiotic cell cycle] GO:0051653 [spindle localization] GO:0060271 [cilium morphogenesis] GO:0070062 [extracellular exosome] Show all	418 aa 47.4 kDa	No	0
ACTR3-003 ENSP00000403125 ENST00000443297	F8WDR7 [Direct mapping] Actin-related protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005885 [Arp2/3 protein complex] GO:0034314 [Arp2/3 complex-mediated actin nucleation] Show all	84 aa 10.1 kDa	No	0
ACTR3-004 ENSP00000407912 ENST00000415792	F8WEW2 [Direct mapping] Actin-related protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		34 aa 3.6 kDa	No	0
ACTR3-008 ENSP00000444987 ENST00000535589	B4DXW1 [Direct mapping] Actin-related protein 3; cDNA FLJ51148, highly similar to Actin-like protein 3; cDNA FLJ52434, highly similar to Actin-like protein 3; cDNA, FLJ79112, highly similar to Actin-like protein 3; cDNA, FLJ79295, highly similar to Actin-like protein 3 Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005885 [Arp2/3 protein complex] GO:0034314 [Arp2/3 complex-mediated actin nucleation] Show all	367 aa 42 kDa	No	0