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ACTR3

GENERAL INFORMATION

Gene name

 ACTR3

Gene description

 ARP3 actin-related protein 3 homolog (yeast)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues. Highest expression in subsets of immune cells in several tissues, including lymphoid organs.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 3 antibodies.
HPA047016 , HPA051683 , CAB005085
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ACTR3 (HGNC Symbol)

Synonyms

 ARP3

Description

 ARP3 actin-related protein 3 homolog (yeast) (HGNC Symbol)

Entrez gene summary

 The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

Chromosome

 2

Cytoband

 q14.1

Chromosome location (bp)

 113889960 - 113962596

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115091 (version 83.38)

Entrez gene

 10096

UniProt

 P61158 (UniProt - Evidence at protein level)

neXtProt

 NX_P61158

Antibodypedia

 ACTR3 antibodies

PROTEIN BROWSER
ACTR3-001
ACTR3-003
ACTR3-004
ACTR3-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACTR3-001
ENSP00000263238
ENST00000263238
P61158 [Direct mapping]
Actin-related protein 3
A0A024RAI1 [Target identity:100%; Query identity:100%]
ARP3 actin-related protein 3 homolog (Yeast), isoform CRA_a
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   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005885 [Arp2/3 protein complex]
GO:0005903 [brush border]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0008356 [asymmetric cell division]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016344 [meiotic chromosome movement towards spindle pole]
GO:0030027 [lamellipodium]
GO:0033206 [meiotic cytokinesis]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051321 [meiotic cell cycle]
GO:0051653 [spindle localization]
GO:0060271 [cilium morphogenesis]
GO:0070062 [extracellular exosome]
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 418 aa
47.4 kDa 		No 0
ACTR3-003
ENSP00000403125
ENST00000443297
F8WDR7 [Direct mapping]
Actin-related protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005885 [Arp2/3 protein complex]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
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 84 aa
10.1 kDa 		No 0
ACTR3-004
ENSP00000407912
ENST00000415792
F8WEW2 [Direct mapping]
Actin-related protein 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 34 aa
3.6 kDa 		No 0
ACTR3-008
ENSP00000444987
ENST00000535589
B4DXW1 [Direct mapping]
Actin-related protein 3; cDNA FLJ51148, highly similar to Actin-like protein 3; cDNA FLJ52434, highly similar to Actin-like protein 3; cDNA, FLJ79112, highly similar to Actin-like protein 3; cDNA, FLJ79295, highly similar to Actin-like protein 3
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   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005885 [Arp2/3 protein complex]
GO:0034314 [Arp2/3 complex-mediated actin nucleation]
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 367 aa
42 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.