Expression of SF3B6 in cancer - Summary

CANCER ATLAS

Gene description

Splicing factor 3b, subunit 6, 14kDa

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA034829	HPA034830

GENE INFORMATION
Gene name	SF3B6 (HGNC Symbol)
Synonyms	CGI-110, Ht006, P14, SAP14a, SF3B14a
Description	Splicing factor 3b, subunit 6, 14kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	24067584 - 24076443
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115128 (version 83.38)
Entrez gene	51639
UniProt	Q9Y3B4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3B4
Antibodypedia	SF3B6 antibodies

PROTEIN BROWSER

SF3B6-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SF3B6-001 ENSP00000233468 ENST00000233468	Q9Y3B4 [Direct mapping] Splicing factor 3B subunit 6 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000398 [mRNA splicing, via spliceosome] GO:0001825 [blastocyst formation] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005684 [U2-type spliceosomal complex] GO:0005686 [U2 snRNP] GO:0005689 [U12-type spliceosomal complex] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0044822 [poly(A) RNA binding] GO:0071011 [precatalytic spliceosome] GO:0071013 [catalytic step 2 spliceosome] Show all	125 aa 14.6 kDa	No	0