Fields »
ABOUT
HELP
BLOG
SF3B6

GENERAL INFORMATION

Gene name

 SF3B6

Gene description

 Splicing factor 3b, subunit 6, 14kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA034829 , HPA034830
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SF3B6 (HGNC Symbol)

Synonyms

 CGI-110, Ht006, P14, SAP14a, SF3B14a

Description

 Splicing factor 3b, subunit 6, 14kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 24067584 - 24076443

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115128 (version 83.38)

Entrez gene

 51639

UniProt

 Q9Y3B4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y3B4

Antibodypedia

 SF3B6 antibodies

PROTEIN BROWSER
SF3B6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SF3B6-001
ENSP00000233468
ENST00000233468
Q9Y3B4 [Direct mapping]
Splicing factor 3B subunit 6
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001825 [blastocyst formation]
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005684 [U2-type spliceosomal complex]
GO:0005686 [U2 snRNP]
GO:0005689 [U12-type spliceosomal complex]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0044822 [poly(A) RNA binding]
GO:0071011 [precatalytic spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 125 aa
14.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.