Expression of STAM2 in cancer - Summary

CANCER ATLAS

Gene description

Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035528	HPA035529

GENE INFORMATION
Gene name	STAM2 (HGNC Symbol)
Synonyms	Hbp
Description	Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q23.3
Chromosome location (bp)	152116801 - 152175992
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115145 (version 83.38)
Entrez gene	10254
UniProt	O75886 (UniProt - Evidence at protein level)
neXtProt	NX_O75886
Antibodypedia	STAM2 antibodies

PROTEIN BROWSER

STAM2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STAM2-001 ENSP00000263904 ENST00000263904	O75886 [Direct mapping] Signal transducing adapter molecule 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006886 [intracellular protein transport] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0016197 [endosomal transport] GO:0031901 [early endosome membrane] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0043231 [intracellular membrane-bounded organelle] GO:0061024 [membrane organization] Show all	525 aa 58.2 kDa	No	0