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STAM2

GENERAL INFORMATION

Gene name

 STAM2

Gene description

 Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression often combined with membranous expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity support the protein profile.

Reliability score

 Supported based on 2 antibodies.
HPA035528 , HPA035529
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 STAM2 (HGNC Symbol)

Synonyms

 Hbp

Description

 Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q23.3

Chromosome location (bp)

 152116801 - 152175992

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115145 (version 83.38)

Entrez gene

 10254

UniProt

 O75886 (UniProt - Evidence at protein level)

neXtProt

 NX_O75886

Antibodypedia

 STAM2 antibodies

PROTEIN BROWSER
STAM2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STAM2-001
ENSP00000263904
ENST00000263904
O75886 [Direct mapping]
Signal transducing adapter molecule 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016197 [endosomal transport]
GO:0031901 [early endosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0061024 [membrane organization]
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 525 aa
58.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.