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Colorectal and breast cancers as well as several cases of ovarian, cervical, skin, testicular and a few cases of malignant melanoma, urothelial and liver cancers showed moderate to strong cytoplasmic positivity. Remaining malignant cells were generally negative.
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001541 [ovarian follicle development] GO:0003743 [translation initiation factor activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005851 [eukaryotic translation initiation factor 2B complex] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006417 [regulation of translation] GO:0009408 [response to heat] GO:0009749 [response to glucose] GO:0010467 [gene expression] GO:0014003 [oligodendrocyte development] GO:0031369 [translation initiation factor binding] GO:0032057 [negative regulation of translational initiation in response to stress] GO:0042552 [myelination] GO:0043434 [response to peptide hormone] GO:0043547 [positive regulation of GTPase activity] GO:0044237 [cellular metabolic process] GO:0044267 [cellular protein metabolic process] GO:0045947 [negative regulation of translational initiation] GO:0051716 [cellular response to stimulus]
