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EIF2B4

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GENERAL INFORMATION

Gene name

 EIF2B4

Gene description

 Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear membrane. In addition localized to the actin filaments.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear membrane (approved)

Additional location

 In addition localized to the Actin filaments (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA039993
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear membrane. In addition localized to the actin filaments.

Main location

 Nuclear membrane (approved)

Additional location

 Actin filaments (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA039993 A-431 Nuclear membrane
Actin filaments
Cytosol
HPA039993 CACO-2 Nuclear membrane
Cytosol
HPA039993 U-2 OS Nuclear membrane
Actin filaments
Cytosol

GENE INFORMATION

Gene name

 EIF2B4 (HGNC Symbol)

Synonyms

 DKFZP586J0119, EIF-2B, EIF2B, EIF2Bdelta

Description

 Eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa (HGNC Symbol)

Entrez gene summary

 Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 27364352 - 27370486

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115211 (version 83.38)

Entrez gene

 8890

UniProt

 Q9UI10 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UI10

Antibodypedia

 EIF2B4 antibodies

PROTEIN BROWSER
EIF2B4-001
EIF2B4-002
EIF2B4-007
EIF2B4-011
EIF2B4-201
EIF2B4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF2B4-001
ENSP00000233552
ENST00000347454
Q9UI10 [Direct mapping]
Translation initiation factor eIF-2B subunit delta
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0003743 [translation initiation factor activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005851 [eukaryotic translation initiation factor 2B complex]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0009408 [response to heat]
GO:0009749 [response to glucose]
GO:0010467 [gene expression]
GO:0014003 [oligodendrocyte development]
GO:0031369 [translation initiation factor binding]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0042552 [myelination]
GO:0043434 [response to peptide hormone]
GO:0043547 [positive regulation of GTPase activity]
GO:0044237 [cellular metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0045947 [negative regulation of translational initiation]
GO:0051716 [cellular response to stimulus]
Show all
 523 aa
57.6 kDa 		No 0
EIF2B4-002
ENSP00000429323
ENST00000493344
E7ERK9 [Direct mapping]
Translation initiation factor eIF-2B subunit delta
Show all
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0044237 [cellular metabolic process]
GO:0045947 [negative regulation of translational initiation]
Show all
 544 aa
59.7 kDa 		No 0
EIF2B4-007
ENSP00000394397
ENST00000445933
Q9UI10 [Direct mapping]
Translation initiation factor eIF-2B subunit delta
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0003743 [translation initiation factor activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005851 [eukaryotic translation initiation factor 2B complex]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0009408 [response to heat]
GO:0009749 [response to glucose]
GO:0010467 [gene expression]
GO:0014003 [oligodendrocyte development]
GO:0031369 [translation initiation factor binding]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0042552 [myelination]
GO:0043434 [response to peptide hormone]
GO:0043547 [positive regulation of GTPase activity]
GO:0044237 [cellular metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0045947 [negative regulation of translational initiation]
GO:0051716 [cellular response to stimulus]
Show all
 522 aa
57.5 kDa 		No 0
EIF2B4-011
ENSP00000394869
ENST00000451130
Q9UI10 [Direct mapping]
Translation initiation factor eIF-2B subunit delta
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0003743 [translation initiation factor activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005851 [eukaryotic translation initiation factor 2B complex]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0009408 [response to heat]
GO:0009749 [response to glucose]
GO:0010467 [gene expression]
GO:0014003 [oligodendrocyte development]
GO:0031369 [translation initiation factor binding]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0042552 [myelination]
GO:0043434 [response to peptide hormone]
GO:0043547 [positive regulation of GTPase activity]
GO:0044237 [cellular metabolic process]
GO:0044267 [cellular protein metabolic process]
GO:0045947 [negative regulation of translational initiation]
GO:0051716 [cellular response to stimulus]
Show all
 543 aa
59.6 kDa 		No 0
EIF2B4-201
ENSP00000477710
ENST00000616081
A0A087WTA5 [Direct mapping]
Translation initiation factor eIF-2B subunit delta
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0044237 [cellular metabolic process]
GO:0045947 [negative regulation of translational initiation]
Show all
 520 aa
57.5 kDa 		No 0
EIF2B4-202
ENSP00000479991
ENST00000622434
A0A087WW69 [Direct mapping]
Translation initiation factor eIF-2B subunit delta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0045947 [negative regulation of translational initiation]
Show all
 228 aa
25.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.