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SNX17

CANCER ATLAS

Gene description

 Sorting nexin 17

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043867

GENE INFORMATION

Gene name

 SNX17 (HGNC Symbol)

Synonyms

 KIAA0064

Description

 Sorting nexin 17 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 27370496 - 27377533

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115234 (version 83.38)

Entrez gene

 9784

UniProt

 Q15036 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15036

Antibodypedia

 SNX17 antibodies

PROTEIN BROWSER
SNX17-001
SNX17-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNX17-001
ENSP00000233575
ENST00000233575
Q15036 [Direct mapping]
Sorting nexin-17
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003279 [cardiac septum development]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006707 [cholesterol catabolic process]
GO:0006886 [intracellular protein transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016197 [endosomal transport]
GO:0030100 [regulation of endocytosis]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0035904 [aorta development]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0060976 [coronary vasculature development]
GO:1990126 [retrograde transport, endosome to plasma membrane]
Show all
 470 aa
52.9 kDa 		No 0
SNX17-201
ENSP00000439208
ENST00000537606
Q15036 [Direct mapping]
Sorting nexin-17
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006707 [cholesterol catabolic process]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016197 [endosomal transport]
GO:0030100 [regulation of endocytosis]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:1990126 [retrograde transport, endosome to plasma membrane]
Show all
 445 aa
50 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.