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SNX17

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GENERAL INFORMATION

Gene name

 SNX17

Gene description

 Sorting nexin 17

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA043867
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to vesicles.

Main location

 Vesicles (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA043867 A-431 Vesicles Intensity
HPA043867 U-2 OS Vesicles
HPA043867 U-251 MG Vesicles Intensity
Cytosol

GENE INFORMATION

Gene name

 SNX17 (HGNC Symbol)

Synonyms

 KIAA0064

Description

 Sorting nexin 17 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

Chromosome

 2

Cytoband

 p23.3

Chromosome location (bp)

 27370496 - 27377533

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115234 (version 83.38)

Entrez gene

 9784

UniProt

 Q15036 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15036

Antibodypedia

 SNX17 antibodies

PROTEIN BROWSER
SNX17-001
SNX17-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNX17-001
ENSP00000233575
ENST00000233575
Q15036 [Direct mapping]
Sorting nexin-17
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003279 [cardiac septum development]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006707 [cholesterol catabolic process]
GO:0006886 [intracellular protein transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016197 [endosomal transport]
GO:0030100 [regulation of endocytosis]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0035904 [aorta development]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0060976 [coronary vasculature development]
GO:1990126 [retrograde transport, endosome to plasma membrane]
Show all
 470 aa
52.9 kDa 		No 0
SNX17-201
ENSP00000439208
ENST00000537606
Q15036 [Direct mapping]
Sorting nexin-17
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006707 [cholesterol catabolic process]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016197 [endosomal transport]
GO:0030100 [regulation of endocytosis]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:1990126 [retrograde transport, endosome to plasma membrane]
Show all
 445 aa
50 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.