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Weak to moderate cytoplasmic immunoreactivity was observed papillary adenocarcinomas of thyroid along with most lymphomas, melanomas, cervical, lung, testicular, urothelial and renal cancers. Remaining cancer tissues were generally negative.
Most cancers were weakly stained or negative. Renal cancers and several cases of urothelial, gastric, testicular and skin cancers showed few cases of moderate cytoplasmic and occasional nuclear immunoreactivity.
GENE INFORMATION
Gene name
GRB14
Synonyms
Description
Growth factor receptor-bound protein 14 (HGNC Symbol)
Entrez gene summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
