Cell atlas - TLX2 - The Human Protein Atlas

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TLX2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TLX2
Gene description	T-cell leukemia homeobox 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enriched (SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA062254
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA062254	SH-SY5Y	Nucleoplasm
	HPA062254	SiHa	Nucleoplasm
	HPA062254	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	TLX2 (HGNC Symbol)
Synonyms	Enx, HOX11L1, NCX, Tlx2
Description	T-cell leukemia homeobox 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010]
Chromosome	2
Cytoband	p13.1
Chromosome location (bp)	74513463 - 74517147
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115297 (version 83.38)
Entrez gene	3196
UniProt	O43763 (UniProt - Evidence at protein level)
neXtProt	NX_O43763
Antibodypedia	TLX2 antibodies

PROTEIN BROWSER

TLX2-001	TLX2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TLX2-001 ENSP00000233638 ENST00000233638	O43763 [Direct mapping] T-cell leukemia homeobox protein 2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001707 [mesoderm formation] GO:0003674 [molecular_function] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0043565 [sequence-specific DNA binding] GO:0048484 [enteric nervous system development] GO:0050774 [negative regulation of dendrite morphogenesis] Show all	284 aa 30.3 kDa	No	0
TLX2-201 ENSP00000482690 ENST00000621092	F1T0F2 [Direct mapping] T-cell leukemia homeobox protein 2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] Show all	235 aa 23.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.