Tissue expression of TLX2 - Summary - The Human Protein Atlas

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TLX2

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TLX2
Gene description	T-cell leukemia homeobox 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (adrenal gland)
GTEx:	Tissue enhanced (testis, small intestine)
FANTOM5:	Tissue enhanced (retina)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA040969
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adrenal gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (retina)

GENE INFORMATION
Gene name	TLX2 (HGNC Symbol)
Synonyms	Enx, HOX11L1, NCX, Tlx2
Description	T-cell leukemia homeobox 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010]
Chromosome	2
Cytoband	p13.1
Chromosome location (bp)	74513463 - 74517147
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115297 (version 83.38)
Entrez gene	3196
UniProt	O43763 (UniProt - Evidence at protein level)
neXtProt	NX_O43763
Antibodypedia	TLX2 antibodies

PROTEIN BROWSER

TLX2-001	TLX2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TLX2-001 ENSP00000233638 ENST00000233638	O43763 [Direct mapping] T-cell leukemia homeobox protein 2 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001707 [mesoderm formation] GO:0003674 [molecular_function] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008150 [biological_process] GO:0043565 [sequence-specific DNA binding] GO:0048484 [enteric nervous system development] GO:0050774 [negative regulation of dendrite morphogenesis] Show all	284 aa 30.3 kDa	No	0
TLX2-201 ENSP00000482690 ENST00000621092	F1T0F2 [Direct mapping] T-cell leukemia homeobox protein 2 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] Show all	235 aa 23.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.