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SPTBN1

CANCER ATLAS

Gene description

 Spectrin, beta, non-erythrocytic 1

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA012685
HPA013149

GENE INFORMATION

Gene name

 SPTBN1

Synonyms

Description

 Spectrin, beta, non-erythrocytic 1 (HGNC Symbol)

Entrez gene summary

 Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p16.2

Chromosome location (bp)

 54456285 - 54671445

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115306 (version 83.38)

Entrez gene

 6711

UniProt

 Q01082 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01082

Antibodypedia

 SPTBN1 antibodies

PROTEIN BROWSER
SPTBN1-001
SPTBN1-002
SPTBN1-003
SPTBN1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SPTBN1-001
ENSP00000349259
ENST00000356805
Q01082 [Direct mapping]
Spectrin beta chain, non-erythrocytic 1
B2ZZ89 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 102; Spectrin beta non-erythrocytic 1; Spectrin, beta, non-erythrocytic 1, isoform CRA_d
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000281 [mitotic cytokinesis]
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007009 [plasma membrane organization]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007182 [common-partner SMAD protein phosphorylation]
GO:0007184 [SMAD protein import into nucleus]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008091 [spectrin]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0016020 [membrane]
GO:0030506 [ankyrin binding]
GO:0030673 [axolemma]
GO:0030863 [cortical cytoskeleton]
GO:0031430 [M band]
GO:0032437 [cuticular plate]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051020 [GTPase binding]
GO:0051693 [actin filament capping]
GO:0070062 [extracellular exosome]
GO:0071709 [membrane assembly]
GO:0072661 [protein targeting to plasma membrane]
GO:0097481 [neuronal postsynaptic density]
GO:1900042 [positive regulation of interleukin-2 secretion]
GO:1903076 [regulation of protein localization to plasma membrane]
GO:1903078 [positive regulation of protein localization to plasma membrane]
Show all
 2364 aa
274.6 kDa 		No 0
SPTBN1-002
ENSP00000334156
ENST00000333896
Q01082 [Direct mapping]
Spectrin beta chain, non-erythrocytic 1
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000281 [mitotic cytokinesis]
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005543 [phospholipid binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007009 [plasma membrane organization]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008091 [spectrin]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0014731 [spectrin-associated cytoskeleton]
GO:0030506 [ankyrin binding]
GO:0030673 [axolemma]
GO:0031430 [M band]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051020 [GTPase binding]
GO:0051693 [actin filament capping]
GO:0070062 [extracellular exosome]
GO:0071709 [membrane assembly]
GO:0072661 [protein targeting to plasma membrane]
GO:1900042 [positive regulation of interleukin-2 secretion]
GO:1903076 [regulation of protein localization to plasma membrane]
GO:1903078 [positive regulation of protein localization to plasma membrane]
Show all
 2155 aa
251.4 kDa 		No 0
SPTBN1-003
ENSP00000374630
ENST00000389980
F8W6C1 [Direct mapping]
Spectrin beta chain, non-erythrocytic 1
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   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
Show all
 690 aa
80.9 kDa 		No 0
SPTBN1-201
ENSP00000479037
ENST00000615901
A0A087WUZ3 [Direct mapping]
Spectrin beta chain, non-erythrocytic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0008091 [spectrin]
Show all
 2366 aa
274.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.