Expression of DOK1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Docking protein 1, 62kDa (downstream of tyrosine kinase 1)

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB004224

GENE INFORMATION
Gene name	DOK1 (HGNC Symbol)
Synonyms	p62dok
Description	Docking protein 1, 62kDa (downstream of tyrosine kinase 1) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Chromosome	2
Cytoband	p13.1
Chromosome location (bp)	74549026 - 74557554
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115325 (version 83.38)
Entrez gene	1796
UniProt	Q99704 (UniProt - Evidence at protein level)
neXtProt	NX_Q99704
Antibodypedia	DOK1 antibodies

PROTEIN BROWSER

DOK1-001	DOK1-002	DOK1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOK1-001 ENSP00000233668 ENST00000233668	Q99704 [Direct mapping] Docking protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005057 [receptor signaling protein activity] GO:0005158 [insulin receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007265 [Ras protein signal transduction] GO:0035556 [intracellular signal transduction] GO:0048471 [perinuclear region of cytoplasm] Show all	481 aa 52.4 kDa	No	0
DOK1-002 ENSP00000344330 ENST00000340004	Q99704 [Direct mapping] Docking protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005158 [insulin receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] Show all	177 aa 19.4 kDa	No	0
DOK1-006 ENSP00000387016 ENST00000409429	Q99704 [Direct mapping] Docking protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005158 [insulin receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] Show all	342 aa 37.4 kDa	No	0