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DOK1

GENERAL INFORMATION

Gene name

 DOK1

Gene description

 Docking protein 1, 62kDa (downstream of tyrosine kinase 1)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 General nucleolar expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB004224
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 DOK1 (HGNC Symbol)

Synonyms

 p62dok

Description

 Docking protein 1, 62kDa (downstream of tyrosine kinase 1) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Chromosome

 2

Cytoband

 p13.1

Chromosome location (bp)

 74549026 - 74557554

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115325 (version 83.38)

Entrez gene

 1796

UniProt

 Q99704 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99704

Antibodypedia

 DOK1 antibodies

PROTEIN BROWSER
DOK1-001
DOK1-002
DOK1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DOK1-001
ENSP00000233668
ENST00000233668
Q99704 [Direct mapping]
Docking protein 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0048471 [perinuclear region of cytoplasm]
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 481 aa
52.4 kDa 		No 0
DOK1-002
ENSP00000344330
ENST00000340004
Q99704 [Direct mapping]
Docking protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 177 aa
19.4 kDa 		No 0
DOK1-006
ENSP00000387016
ENST00000409429
Q99704 [Direct mapping]
Docking protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 342 aa
37.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.