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RNA cell line category: Cell line enhanced (HeLa, RPTEC TERT1, U-2 OS, HEK 293)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
ACADL (HGNC Symbol)
Synonyms
ACAD4, LCAD
Description
Acyl-CoA dehydrogenase, long chain (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]
P28330 [Direct mapping] Long-chain specific acyl-CoA dehydrogenase, mitochondrial
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Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000062 [fatty-acyl-CoA binding] GO:0001659 [temperature homeostasis] GO:0003995 [acyl-CoA dehydrogenase activity] GO:0004466 [long-chain-acyl-CoA dehydrogenase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0009055 [electron carrier activity] GO:0016401 [palmitoyl-CoA oxidase activity] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0019254 [carnitine metabolic process, CoA-linked] GO:0031966 [mitochondrial membrane] GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase] GO:0042413 [carnitine catabolic process] GO:0042758 [long-chain fatty acid catabolic process] GO:0044242 [cellular lipid catabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0046322 [negative regulation of fatty acid oxidation] GO:0050660 [flavin adenine dinucleotide binding] GO:0051289 [protein homotetramerization] GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor] GO:0055088 [lipid homeostasis] GO:0055114 [oxidation-reduction process] GO:0090181 [regulation of cholesterol metabolic process]
