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The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]
P28330 [Direct mapping] Long-chain specific acyl-CoA dehydrogenase, mitochondrial
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Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000062 [fatty-acyl-CoA binding] GO:0001659 [temperature homeostasis] GO:0003995 [acyl-CoA dehydrogenase activity] GO:0004466 [long-chain-acyl-CoA dehydrogenase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0009055 [electron carrier activity] GO:0016401 [palmitoyl-CoA oxidase activity] GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors] GO:0019254 [carnitine metabolic process, CoA-linked] GO:0031966 [mitochondrial membrane] GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase] GO:0042413 [carnitine catabolic process] GO:0042758 [long-chain fatty acid catabolic process] GO:0044242 [cellular lipid catabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0046322 [negative regulation of fatty acid oxidation] GO:0050660 [flavin adenine dinucleotide binding] GO:0051289 [protein homotetramerization] GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor] GO:0055088 [lipid homeostasis] GO:0055114 [oxidation-reduction process] GO:0090181 [regulation of cholesterol metabolic process]
