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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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REG1A
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

REG1A

Gene description

Regenerating islet-derived 1 alpha

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (pancreas, duodenum, small intestine)
GTEx:Tissue enriched (pancreas)
FANTOM5:Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in exocrine pancreas and the small intestine.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Supported based on 3 antibodies.
HPA045549 , HPA045579 , CAB025138
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pancreas, duodenum, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pancreas)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pancreas)

GENE INFORMATION

Gene name

REG1A (HGNC Symbol)

Synonyms

PSP, PSPS, PSPS1, PTP, REG

Description

Regenerating islet-derived 1 alpha (HGNC Symbol)

Entrez gene summary

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

p12

Chromosome location (bp)

79120362 - 79123419

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000115386 (version 83.38)

Entrez gene

5967

UniProt

P05451 (UniProt - Evidence at protein level)

neXtProt

NX_P05451

Antibodypedia

REG1A antibodies

PROTEIN BROWSER

REG1A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

REG1A-001
ENSP00000233735
ENST00000233735
P05451 [Direct mapping]
Lithostathine-1-alpha
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0030246 [carbohydrate binding]
GO:0070062 [extracellular exosome]
Show all
166 aa
18.7 kDa
Yes 0

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