Expression of FANCL in cancer - Summary

CANCER ATLAS

Gene description

Fanconi anemia, complementation group L

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA036685	HPA036686	CAB033842

GENE INFORMATION
Gene name	FANCL (HGNC Symbol)
Synonyms	FAAP43, FLJ10335, PHF9, Pog
Description	Fanconi anemia, complementation group L (HGNC Symbol)
Entrez gene summary	The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p16.1
Chromosome location (bp)	58159243 - 58241372
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115392 (version 83.38)
Entrez gene	55120
UniProt	Q9NW38 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NW38
Antibodypedia	FANCL antibodies

PROTEIN BROWSER

FANCL-001	FANCL-002	FANCL-003	FANCL-004	FANCL-005	FANCL-006	FANCL-007	FANCL-008	FANCL-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FANCL-001 ENSP00000233741 ENST00000233741	Q9NW38 [Direct mapping] E3 ubiquitin-protein ligase FANCL Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006513 [protein monoubiquitination] GO:0006974 [cellular response to DNA damage stimulus] GO:0008270 [zinc ion binding] GO:0016874 [ligase activity] GO:0031625 [ubiquitin protein ligase binding] GO:0036297 [interstrand cross-link repair] GO:0043240 [Fanconi anaemia nuclear complex] GO:0061630 [ubiquitin protein ligase activity] Show all	375 aa 42.9 kDa	No	0
FANCL-002 ENSP00000385021 ENST00000402135	Q9NW38 [Direct mapping] E3 ubiquitin-protein ligase FANCL Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006513 [protein monoubiquitination] GO:0006974 [cellular response to DNA damage stimulus] GO:0007276 [gamete generation] GO:0008270 [zinc ion binding] GO:0016874 [ligase activity] GO:0031625 [ubiquitin protein ligase binding] GO:0036297 [interstrand cross-link repair] GO:0042127 [regulation of cell proliferation] GO:0043240 [Fanconi anaemia nuclear complex] GO:0061630 [ubiquitin protein ligase activity] Show all	380 aa 43.4 kDa	No	0
FANCL-003 ENSP00000401280 ENST00000449070	C9JZA9 [Direct mapping] E3 ubiquitin-protein ligase FANCL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0006281 [DNA repair] GO:0016567 [protein ubiquitination] GO:0043240 [Fanconi anaemia nuclear complex] Show all	301 aa 34.1 kDa	No	0
FANCL-004 ENSP00000386097 ENST00000403295	B5MC31 [Direct mapping] E3 ubiquitin-protein ligase FANCL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043240 [Fanconi anaemia nuclear complex] Show all	347 aa 39.8 kDa	No	0
FANCL-005 ENSP00000389448 ENST00000417361	C9JPN7 [Direct mapping] E3 ubiquitin-protein ligase FANCL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		145 aa 16.4 kDa	No	0
FANCL-006 ENSP00000384046 ENST00000403676	B5MCZ6 [Direct mapping] E3 ubiquitin-protein ligase FANCL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004842 [ubiquitin-protein transferase activity] GO:0006281 [DNA repair] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0043240 [Fanconi anaemia nuclear complex] Show all	258 aa 29.4 kDa	No	0
FANCL-007 ENSP00000390991 ENST00000446381	C9J512 [Direct mapping] E3 ubiquitin-protein ligase FANCL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		158 aa 17.9 kDa	No	0
FANCL-008 ENSP00000483263 ENST00000481670	A0A087X0C0 [Direct mapping] E3 ubiquitin-protein ligase FANCL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 14.4 kDa	No	0
FANCL-009 ENSP00000400969 ENST00000427708	H7C1M0 [Direct mapping] E3 ubiquitin-protein ligase FANCL Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		288 aa 32.7 kDa	No	0