Cell atlas - USP34 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

USP34

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	USP34
Gene description	Ubiquitin specific peptidase 34
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA070764
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA070764	MCF7	Nucleus
	HPA070764	SK-MEL-30	Nucleus
	HPA070764	U-2 OS	Nucleus

GENE INFORMATION
Gene name	USP34 (HGNC Symbol)
Synonyms	KIAA0570, KIAA0729
Description	Ubiquitin specific peptidase 34 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p15
Chromosome location (bp)	61187463 - 61470769
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115464 (version 83.38)
Entrez gene	9736
UniProt	Q70CQ2 (UniProt - Evidence at protein level)
neXtProt	NX_Q70CQ2
Antibodypedia	USP34 antibodies

PROTEIN BROWSER

USP34-001	USP34-002	USP34-005	USP34-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP34-001 ENSP00000381577 ENST00000398571	Q70CQ2 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 34 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016055 [Wnt signaling pathway] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] GO:0071108 [protein K48-linked deubiquitination] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	3546 aa 404.2 kDa	No	0
USP34-002 ENSP00000398960 ENST00000411912	H7C183 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 34 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	1223 aa 140.1 kDa	No	0
USP34-005 ENSP00000398489 ENST00000436269	H7C150 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 34 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	424 aa 47.5 kDa	No	0
USP34-006 ENSP00000410559 ENST00000453734	A0A0C4DG73 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0008234 [cysteine-type peptidase activity] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	810 aa 94.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.