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Rare cases of non Hodgkins lymphomas displayed strong cytoplasmic and nuclear staining. Remaining malignant cells were in general negative.
GENE INFORMATION
Gene name
GNLY (HGNC Symbol)
Synonyms
D2S69E, LAG-2, LAG2, NKG5, TLA519
Description
Granulysin (HGNC Symbol)
Entrez gene summary
The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transporters Transporter channels and pores Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005615 [extracellular space] GO:0006968 [cellular defense response] GO:0031640 [killing of cells of other organism] GO:0042742 [defense response to bacterium] GO:0050832 [defense response to fungus]
Transporters Transporter channels and pores Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005615 [extracellular space] GO:0006968 [cellular defense response] GO:0031640 [killing of cells of other organism] GO:0042742 [defense response to bacterium] GO:0050832 [defense response to fungus]
