Expression of HSPE1 in cancer - Summary

CANCER ATLAS

Gene description

Heat shock 10kDa protein 1

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA038755	HPA048272	CAB017366

GENE INFORMATION
Gene name	HSPE1 (HGNC Symbol)
Synonyms	CPN10, EPF, GroES, HSP10
Description	Heat shock 10kDa protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	197499994 - 197503457
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115541 (version 83.38)
Entrez gene	3336
UniProt	P61604 (UniProt - Evidence at protein level)
neXtProt	NX_P61604
Antibodypedia	HSPE1 antibodies

PROTEIN BROWSER

HSPE1-001	HSPE1-002	HSPE1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HSPE1-001 ENSP00000233893 ENST00000233893	P61604 [Direct mapping] 10 kDa heat shock protein, mitochondrial Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001649 [osteoblast differentiation] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006457 [protein folding] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006986 [response to unfolded protein] GO:0016020 [membrane] GO:0044822 [poly(A) RNA binding] GO:0051082 [unfolded protein binding] GO:0051087 [chaperone binding] GO:0070062 [extracellular exosome] Show all	102 aa 10.9 kDa	No	0
HSPE1-002 ENSP00000387101 ENST00000409729	B8ZZ54 [Direct mapping] 10 kDa heat shock protein, mitochondrial; Heat shock 10kDa protein 1 (Chaperonin 10), isoform CRA_h Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006457 [protein folding] Show all	47 aa 5.2 kDa	No	0
HSPE1-004 ENSP00000386447 ENST00000409468	B8ZZL8 [Direct mapping] 10 kDa heat shock protein, mitochondrial; Heat shock 10kDa protein 1 (Chaperonin 10), isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006457 [protein folding] Show all	101 aa 10.7 kDa	No	0