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HSPE1

GENERAL INFORMATION

Gene name

 HSPE1

Gene description

 Heat shock 10kDa protein 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA038755 , HPA048272 , CAB017366
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HSPE1 (HGNC Symbol)

Synonyms

 CPN10, EPF, GroES, HSP10

Description

 Heat shock 10kDa protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 197499994 - 197503457

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115541 (version 83.38)

Entrez gene

 3336

UniProt

 P61604 (UniProt - Evidence at protein level)

neXtProt

 NX_P61604

Antibodypedia

 HSPE1 antibodies

PROTEIN BROWSER
HSPE1-001
HSPE1-002
HSPE1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSPE1-001
ENSP00000233893
ENST00000233893
P61604 [Direct mapping]
10 kDa heat shock protein, mitochondrial
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006457 [protein folding]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006986 [response to unfolded protein]
GO:0016020 [membrane]
GO:0044822 [poly(A) RNA binding]
GO:0051082 [unfolded protein binding]
GO:0051087 [chaperone binding]
GO:0070062 [extracellular exosome]
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 102 aa
10.9 kDa 		No 0
HSPE1-002
ENSP00000387101
ENST00000409729
B8ZZ54 [Direct mapping]
10 kDa heat shock protein, mitochondrial; Heat shock 10kDa protein 1 (Chaperonin 10), isoform CRA_h
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005737 [cytoplasm]
GO:0006457 [protein folding]
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 47 aa
5.2 kDa 		No 0
HSPE1-004
ENSP00000386447
ENST00000409468
B8ZZL8 [Direct mapping]
10 kDa heat shock protein, mitochondrial; Heat shock 10kDa protein 1 (Chaperonin 10), isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006457 [protein folding]
Show all
 101 aa
10.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.