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IL1RL2

GENERAL INFORMATION

Gene name

 IL1RL2

Gene description

 Interleukin 1 receptor-like 2

Protein class

 Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skin)
GTEx:Tissue enhanced (skin)
FANTOM5:Tissue enhanced (seminal vesicle, esophagus)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA015485
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle, esophagus)

GENE INFORMATION

Gene name

 IL1RL2 (HGNC Symbol)

Synonyms

 IL1R-rp2, IL1RRP2

Description

 Interleukin 1 receptor-like 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q12.1

Chromosome location (bp)

 102186973 - 102240002

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115598 (version 83.38)

Entrez gene

 8808

UniProt

 Q9HB29 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HB29

Antibodypedia

 IL1RL2 antibodies

PROTEIN BROWSER
IL1RL2-001
IL1RL2-003
IL1RL2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL1RL2-001
ENSP00000264257
ENST00000264257
Q9HB29 [Direct mapping]
Interleukin-1 receptor-like 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004908 [interleukin-1 receptor activity]
GO:0004909 [interleukin-1, Type I, activating receptor activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0045087 [innate immune response]
GO:0045582 [positive regulation of T cell differentiation]
GO:0050727 [regulation of inflammatory response]
GO:0070498 [interleukin-1-mediated signaling pathway]
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 575 aa
65.4 kDa 		Yes 1
IL1RL2-003
ENSP00000387611
ENST00000421464
C9K0I8 [Direct mapping]
Interleukin-1 receptor-like 2
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0005515 [protein binding]
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 172 aa
19.5 kDa 		Yes 0
IL1RL2-201
ENSP00000413348
ENST00000441515
Q9HB29 [Direct mapping]
Interleukin-1 receptor-like 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004908 [interleukin-1 receptor activity]
GO:0004909 [interleukin-1, Type I, activating receptor activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006968 [cellular defense response]
GO:0007165 [signal transduction]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0045087 [innate immune response]
GO:0070498 [interleukin-1-mediated signaling pathway]
Show all
 457 aa
51.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.