Fields »
ABOUT
HELP
BLOG
FHL2

GENERAL INFORMATION

Gene name

 FHL2

Gene description

 Four and a half LIM domains 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Tissue enhanced (ovary, heart muscle)
FANTOM5:Group enriched (heart muscle, ovary)

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression, highest in heart muscle, ovary and endometrium.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA005922 , HPA006028 , CAB008368
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (ovary, heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, ovary)

GENE INFORMATION

Gene name

 FHL2 (HGNC Symbol)

Synonyms

 DRAL, SLIM3

Description

 Four and a half LIM domains 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011]

Chromosome

 2

Cytoband

 q12.2

Chromosome location (bp)

 105357712 - 105438513

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115641 (version 83.38)

Entrez gene

 2274

UniProt

 Q14192 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14192

Antibodypedia

 FHL2 antibodies

PROTEIN BROWSER
FHL2-001
FHL2-002
FHL2-003
FHL2-004
FHL2-005
FHL2-006
FHL2-007
FHL2-009
FHL2-011
FHL2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FHL2-001
ENSP00000386665
ENST00000409807
Q14192 [Direct mapping]
Four and a half LIM domains protein 2
Q6I9R8 [Target identity:100%; Query identity:100%]
FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001649 [osteoblast differentiation]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009725 [response to hormone]
GO:0015629 [actin cytoskeleton]
GO:0030018 [Z disc]
GO:0030521 [androgen receptor signaling pathway]
GO:0031430 [M band]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
GO:0055014 [atrial cardiac muscle cell development]
GO:0055015 [ventricular cardiac muscle cell development]
GO:0060347 [heart trabecula formation]
Show all
 279 aa
32.2 kDa 		No 0
FHL2-002
ENSP00000344266
ENST00000344213
J3KNW4 [Direct mapping]
Four and a half LIM domains protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
Show all
 389 aa
44.2 kDa 		No 0
FHL2-003
ENSP00000377021
ENST00000393353
Q14192 [Direct mapping]
Four and a half LIM domains protein 2
Q6I9R8 [Target identity:100%; Query identity:100%]
FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009725 [response to hormone]
GO:0015629 [actin cytoskeleton]
GO:0030521 [androgen receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
Show all
 279 aa
32.2 kDa 		No 0
FHL2-004
ENSP00000322909
ENST00000322142
Q14192 [Direct mapping]
Four and a half LIM domains protein 2
Q6I9R8 [Target identity:100%; Query identity:100%]
FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009725 [response to hormone]
GO:0015629 [actin cytoskeleton]
GO:0030521 [androgen receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
Show all
 279 aa
32.2 kDa 		No 0
FHL2-005
ENSP00000386633
ENST00000408995
Q14192 [Direct mapping]
Four and a half LIM domains protein 2
Q6I9R8 [Target identity:100%; Query identity:100%]
FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009725 [response to hormone]
GO:0015629 [actin cytoskeleton]
GO:0030521 [androgen receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
Show all
 279 aa
32.2 kDa 		No 0
FHL2-006
ENSP00000386892
ENST00000409177
A0A0A0MSG2 [Direct mapping]
Four and a half LIM domains protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 395 aa
44.8 kDa 		No 0
FHL2-007
ENSP00000397083
ENST00000447958
C9J3S8 [Direct mapping]
Four and a half LIM domains protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 19 aa
2.3 kDa 		No 0
FHL2-009
ENSP00000377020
ENST00000393352
Q14192 [Direct mapping]
Four and a half LIM domains protein 2
Q6I9R8 [Target identity:100%; Query identity:100%]
FHL2 protein; Four and a half LIM domains 2; HCG28013, isoform CRA_a; cDNA, FLJ94468, Homo sapiens four and a half LIM domains 2 (FHL2), mRNA
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009725 [response to hormone]
GO:0015629 [actin cytoskeleton]
GO:0030521 [androgen receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
Show all
 279 aa
32.2 kDa 		No 0
FHL2-011
ENSP00000476199
ENST00000607522
U3KQT4 [Direct mapping]
Four and a half LIM domains protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008270 [zinc ion binding]
Show all
 65 aa
7.2 kDa 		No 0
FHL2-201
ENSP00000350846
ENST00000358129
Q14192 [Direct mapping]
Four and a half LIM domains protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005925 [focal adhesion]
GO:0006351 [transcription, DNA-templated]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0009725 [response to hormone]
GO:0015629 [actin cytoskeleton]
GO:0030521 [androgen receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050681 [androgen receptor binding]
Show all
 151 aa
15.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.