Expression of DCAF17 in cancer - Summary

CANCER ATLAS

Gene description

DDB1 and CUL4 associated factor 17

Protein class

Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA053339	HPA055040

GENE INFORMATION
Gene name	DCAF17 (HGNC Symbol)
Synonyms	C2orf37, FLJ13096
Description	DDB1 and CUL4 associated factor 17 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear transmembrane protein that associates with cullin 4A/damaged DNA binding protein 1 ubiquitin ligase complex. Mutations in this gene are associated with Woodhouse-Sakati syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	171434217 - 171485052
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115827 (version 83.38)
Entrez gene	80067
UniProt	Q5H9S7 (UniProt - Evidence at protein level)
neXtProt	NX_Q5H9S7
Antibodypedia	DCAF17 antibodies

PROTEIN BROWSER

DCAF17-001	DCAF17-003	DCAF17-008	DCAF17-201	DCAF17-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DCAF17-001 ENSP00000364404 ENST00000375255	Q5H9S7 [Direct mapping] DDB1- and CUL4-associated factor 17 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005730 [nucleolus] GO:0016021 [integral component of membrane] GO:0016567 [protein ubiquitination] GO:0080008 [Cul4-RING E3 ubiquitin ligase complex] Show all	520 aa 58.8 kDa	No	1
DCAF17-003 ENSP00000342160 ENST00000339506	H0Y2X0 [Direct mapping] DDB1- and CUL4-associated factor 17 Show all	Predicted intracellular proteins Show all		271 aa 30.9 kDa	No	0
DCAF17-008 ENSP00000403992 ENST00000431110	H7C244 [Direct mapping] DDB1- and CUL4-associated factor 17 Show all	Predicted intracellular proteins Show all		222 aa 25.3 kDa	No	0
DCAF17-201 ENSP00000442238 ENST00000539783	F5H7W1 [Direct mapping] DDB1- and CUL4-associated factor 17 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all		453 aa 51.1 kDa	No	1
DCAF17-202 ENSP00000477604 ENST00000611110	Q5H9S7 [Direct mapping] DDB1- and CUL4-associated factor 17 Show all	Predicted intracellular proteins Disease related genes Show all	GO:0005730 [nucleolus] GO:0016021 [integral component of membrane] GO:0016567 [protein ubiquitination] GO:0080008 [Cul4-RING E3 ubiquitin ligase complex] Show all	240 aa 27.5 kDa	No	0