Expression of QPCT in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glutaminyl-peptide cyclotransferase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA008406

GENE INFORMATION
Gene name	QPCT (HGNC Symbol)
Synonyms	GCT, QC
Description	Glutaminyl-peptide cyclotransferase (HGNC Symbol)
Entrez gene summary	This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p22.2
Chromosome location (bp)	37344574 - 37373322
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115828 (version 83.38)
Entrez gene	25797
UniProt	Q16769 (UniProt - Evidence at protein level)
neXtProt	NX_Q16769
Antibodypedia	QPCT antibodies

PROTEIN BROWSER

QPCT-001	QPCT-004	QPCT-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
QPCT-001 ENSP00000344829 ENST00000338415	Q16769 [Direct mapping] Glutaminyl-peptide cyclotransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006464 [cellular protein modification process] GO:0008270 [zinc ion binding] GO:0016603 [glutaminyl-peptide cyclotransferase activity] GO:0017186 [peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase] GO:0070062 [extracellular exosome] Show all	361 aa 40.9 kDa	Yes	0
QPCT-004 ENSP00000385391 ENST00000404976	B5MCZ9 [Direct mapping] Glutaminyl-peptide cyclotransferase Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		284 aa 32.1 kDa	Yes	0
QPCT-006 ENSP00000389227 ENST00000444022	C9JS14 [Direct mapping] Glutaminyl-peptide cyclotransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		118 aa 13.6 kDa	No	0