Cell atlas - QPCT - The Human Protein Atlas

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QPCT

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	QPCT
Gene description	Glutaminyl-peptide cyclotransferase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (SK-MEL-30, U-266/84, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA008406
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-MEL-30, U-266/84, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA008406	HEK 293	Cytosol
	HPA008406	SK-MEL-30	Cytosol
	HPA008406	U-2 OS	Cytosol

GENE INFORMATION
Gene name	QPCT (HGNC Symbol)
Synonyms	GCT, QC
Description	Glutaminyl-peptide cyclotransferase (HGNC Symbol)
Entrez gene summary	This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p22.2
Chromosome location (bp)	37344574 - 37373322
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115828 (version 83.38)
Entrez gene	25797
UniProt	Q16769 (UniProt - Evidence at protein level)
neXtProt	NX_Q16769
Antibodypedia	QPCT antibodies

PROTEIN BROWSER

QPCT-001	QPCT-004	QPCT-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
QPCT-001 ENSP00000344829 ENST00000338415	Q16769 [Direct mapping] Glutaminyl-peptide cyclotransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006464 [cellular protein modification process] GO:0008270 [zinc ion binding] GO:0016603 [glutaminyl-peptide cyclotransferase activity] GO:0017186 [peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase] GO:0070062 [extracellular exosome] Show all	361 aa 40.9 kDa	Yes	0
QPCT-004 ENSP00000385391 ENST00000404976	B5MCZ9 [Direct mapping] Glutaminyl-peptide cyclotransferase Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		284 aa 32.1 kDa	Yes	0
QPCT-006 ENSP00000389227 ENST00000444022	C9JS14 [Direct mapping] Glutaminyl-peptide cyclotransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		118 aa 13.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.