Expression of SLC25A12 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 25 (aspartate/glutamate carrier), member 12

Protein class

Disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035333	HPA035334

GENE INFORMATION
Gene name	SLC25A12 (HGNC Symbol)
Synonyms	Aralar
Description	Solute carrier family 25 (aspartate/glutamate carrier), member 12 (HGNC Symbol)
Entrez gene summary	This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	171784370 - 171999859
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115840 (version 83.38)
Entrez gene	8604
UniProt	O75746 (UniProt - Evidence at protein level)
neXtProt	NX_O75746
Antibodypedia	SLC25A12 antibodies

PROTEIN BROWSER

SLC25A12-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A12-001 ENSP00000388658 ENST00000422440	O75746 [Direct mapping] Calcium-binding mitochondrial carrier protein Aralar1 Show all	Transporters Electrochemical Potential-driven transporters MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005313 [L-glutamate transmembrane transporter activity] GO:0005509 [calcium ion binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0015183 [L-aspartate transmembrane transporter activity] GO:0015810 [aspartate transport] GO:0015813 [L-glutamate transport] GO:0016021 [integral component of membrane] GO:0043209 [myelin sheath] GO:0043490 [malate-aspartate shuttle] GO:0044281 [small molecule metabolic process] GO:0051592 [response to calcium ion] GO:0089711 [L-glutamate transmembrane transport] GO:0089712 [L-aspartate transmembrane transport] Show all	678 aa 74.8 kDa	No	0