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SLC25A12

GENERAL INFORMATION

Gene name

 SLC25A12

Gene description

 Solute carrier family 25 (aspartate/glutamate carrier), member 12

Protein class

 Disease related genes
Potential drug targets
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA035333 , HPA035334
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SLC25A12 (HGNC Symbol)

Synonyms

 Aralar

Description

 Solute carrier family 25 (aspartate/glutamate carrier), member 12 (HGNC Symbol)

Entrez gene summary

 This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 171784370 - 171999859

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115840 (version 83.38)

Entrez gene

 8604

UniProt

 O75746 (UniProt - Evidence at protein level)

neXtProt

 NX_O75746

Antibodypedia

 SLC25A12 antibodies

PROTEIN BROWSER
SLC25A12-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC25A12-001
ENSP00000388658
ENST00000422440
O75746 [Direct mapping]
Calcium-binding mitochondrial carrier protein Aralar1
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Transporters
   Electrochemical Potential-driven transporters
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005509 [calcium ion binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0015183 [L-aspartate transmembrane transporter activity]
GO:0015810 [aspartate transport]
GO:0015813 [L-glutamate transport]
GO:0016021 [integral component of membrane]
GO:0043209 [myelin sheath]
GO:0043490 [malate-aspartate shuttle]
GO:0044281 [small molecule metabolic process]
GO:0051592 [response to calcium ion]
GO:0089711 [L-glutamate transmembrane transport]
GO:0089712 [L-aspartate transmembrane transport]
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 678 aa
74.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.