Expression of PLCL1 in cancer - Summary

CANCER ATLAS

Gene description

Phospholipase C-like 1

Protein class

FDA approved drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA031849

GENE INFORMATION
Gene name	PLCL1 (HGNC Symbol)
Synonyms	PLC-L, PLCE, PLCL, PPP1R127, PRIP
Description	Phospholipase C-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q33.1
Chromosome location (bp)	197804702 - 198572581
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115896 (version 83.38)
Entrez gene	5334
UniProt	Q15111 (UniProt - Evidence at protein level)
neXtProt	NX_Q15111
Antibodypedia	PLCL1 antibodies

PROTEIN BROWSER

PLCL1-002	PLCL1-006	PLCL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLCL1-002 ENSP00000457588 ENST00000487695	H3BUD4 [Direct mapping] Phosphoinositide phospholipase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006629 [lipid metabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0016042 [lipid catabolic process] GO:0035556 [intracellular signal transduction] Show all	1012 aa 114.7 kDa	No	0
PLCL1-006 ENSP00000402861 ENST00000428675	Q15111 [Direct mapping] Inactive phospholipase C-like protein 1 Show all	Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004629 [phospholipase C activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006629 [lipid metabolic process] GO:0007165 [signal transduction] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0008081 [phosphoric diester hydrolase activity] GO:0032228 [regulation of synaptic transmission, GABAergic] GO:0033135 [regulation of peptidyl-serine phosphorylation] GO:0035556 [intracellular signal transduction] GO:1900122 [positive regulation of receptor binding] Show all	1095 aa 122.7 kDa	No	0
PLCL1-201 ENSP00000414138 ENST00000437704	A0A0A0MT40 [Direct mapping] Phosphoinositide phospholipase C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0006629 [lipid metabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0016042 [lipid catabolic process] GO:0035556 [intracellular signal transduction] Show all	1018 aa 115.3 kDa	No	0