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PLCL1

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GENERAL INFORMATION

Gene name

 PLCL1

Gene description

 Phospholipase C-like 1

Protein class

 FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (K-562, MOLT-4, Karpas-707, HUVEC TERT2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (K-562, MOLT-4, Karpas-707, HUVEC TERT2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 PLCL1 (HGNC Symbol)

Synonyms

 PLC-L, PLCE, PLCL, PPP1R127, PRIP

Description

 Phospholipase C-like 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 197804702 - 198572581

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115896 (version 83.38)

Entrez gene

 5334

UniProt

 Q15111 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15111

Antibodypedia

 PLCL1 antibodies

PROTEIN BROWSER
PLCL1-002
PLCL1-006
PLCL1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLCL1-002
ENSP00000457588
ENST00000487695
H3BUD4 [Direct mapping]
Phosphoinositide phospholipase C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
Show all
 1012 aa
114.7 kDa 		No 0
PLCL1-006
ENSP00000402861
ENST00000428675
Q15111 [Direct mapping]
Inactive phospholipase C-like protein 1
Show all
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0032228 [regulation of synaptic transmission, GABAergic]
GO:0033135 [regulation of peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:1900122 [positive regulation of receptor binding]
Show all
 1095 aa
122.7 kDa 		No 0
PLCL1-201
ENSP00000414138
ENST00000437704
A0A0A0MT40 [Direct mapping]
Phosphoinositide phospholipase C
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
Show all
 1018 aa
115.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.