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WIPF1

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GENERAL INFORMATION

Gene name

 WIPF1

Gene description

 WAS/WASL interacting protein family, member 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane.

RNA cell category

 Cell line enhanced (Karpas-707)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Additional location

 In addition localized to the Plasma membrane (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA070706
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the plasma membrane.

Main location

 Cytosol (approved)

Additional location

 Plasma membrane (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA070706 HeLa Plasma membrane
Cytosol
HPA070706 SH-SY5Y Cytosol Intensity
HPA070706 U-2 OS Cytosol

GENE INFORMATION

Gene name

 WIPF1 (HGNC Symbol)

Synonyms

 WASPIP, WIP

Description

 WAS/WASL interacting protein family, member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 174559572 - 174682916

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115935 (version 83.38)

Entrez gene

 7456

UniProt

 O43516 (UniProt - Evidence at protein level)

neXtProt

 NX_O43516

Antibodypedia

 WIPF1 antibodies

PROTEIN BROWSER
WIPF1-001
WIPF1-002
WIPF1-003
WIPF1-004
WIPF1-005
WIPF1-006
WIPF1-014
WIPF1-016
WIPF1-017
WIPF1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WIPF1-001
ENSP00000376330
ENST00000392547
O43516 [Direct mapping]
WAS/WASL-interacting protein family member 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000147 [actin cortical patch assembly]
GO:0001726 [ruffle]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006461 [protein complex assembly]
GO:0006897 [endocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008154 [actin polymerization or depolymerization]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030048 [actin filament-based movement]
GO:0030479 [actin cortical patch]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0051015 [actin filament binding]
GO:0051127 [positive regulation of actin nucleation]
GO:0051666 [actin cortical patch localization]
GO:0051707 [response to other organism]
Show all
 503 aa
51.3 kDa 		No 0
WIPF1-002
ENSP00000376329
ENST00000392546
O43516 [Direct mapping]
WAS/WASL-interacting protein family member 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000147 [actin cortical patch assembly]
GO:0001726 [ruffle]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006461 [protein complex assembly]
GO:0006897 [endocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008154 [actin polymerization or depolymerization]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030048 [actin filament-based movement]
GO:0030479 [actin cortical patch]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0051015 [actin filament binding]
GO:0051127 [positive regulation of actin nucleation]
GO:0051666 [actin cortical patch localization]
Show all
 503 aa
51.3 kDa 		No 0
WIPF1-003
ENSP00000387150
ENST00000409415
E9PB87 [Direct mapping]
WAS/WASL-interacting protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
Show all
 403 aa
40.5 kDa 		No 0
WIPF1-004
ENSP00000272746
ENST00000272746
O43516 [Direct mapping]
WAS/WASL-interacting protein family member 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000147 [actin cortical patch assembly]
GO:0001726 [ruffle]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006461 [protein complex assembly]
GO:0006897 [endocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008154 [actin polymerization or depolymerization]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030048 [actin filament-based movement]
GO:0030479 [actin cortical patch]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0051015 [actin filament binding]
GO:0051127 [positive regulation of actin nucleation]
GO:0051666 [actin cortical patch localization]
Show all
 510 aa
52 kDa 		No 0
WIPF1-005
ENSP00000386431
ENST00000409891
O43516 [Direct mapping]
WAS/WASL-interacting protein family member 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000147 [actin cortical patch assembly]
GO:0001726 [ruffle]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006461 [protein complex assembly]
GO:0006897 [endocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008154 [actin polymerization or depolymerization]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030048 [actin filament-based movement]
GO:0030479 [actin cortical patch]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0051015 [actin filament binding]
GO:0051127 [positive regulation of actin nucleation]
GO:0051666 [actin cortical patch localization]
Show all
 493 aa
50.3 kDa 		No 0
WIPF1-006
ENSP00000352802
ENST00000359761
O43516 [Direct mapping]
WAS/WASL-interacting protein family member 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000147 [actin cortical patch assembly]
GO:0001726 [ruffle]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005522 [profilin binding]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0006461 [protein complex assembly]
GO:0006897 [endocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008154 [actin polymerization or depolymerization]
GO:0008360 [regulation of cell shape]
GO:0015629 [actin cytoskeleton]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0030048 [actin filament-based movement]
GO:0030479 [actin cortical patch]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0051015 [actin filament binding]
GO:0051127 [positive regulation of actin nucleation]
GO:0051666 [actin cortical patch localization]
Show all
 503 aa
51.3 kDa 		No 0
WIPF1-014
ENSP00000388454
ENST00000436221
C9JTB9 [Direct mapping]
WAS/WASL-interacting protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
Show all
 100 aa
9.3 kDa 		No 0
WIPF1-016
ENSP00000386757
ENST00000410117
B8ZZ90 [Direct mapping]
WAS/WASL-interacting protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
Show all
 131 aa
12.5 kDa 		No 0
WIPF1-017
ENSP00000391785
ENST00000455428
C9JB04 [Direct mapping]
WAS/WASL-interacting protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
Show all
 157 aa
15.1 kDa 		No 0
WIPF1-201
ENSP00000479992
ENST00000610916
A0A087WW70 [Direct mapping]
WAS/WASL-interacting protein family member 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
Show all
 492 aa
50.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.