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RND3

GENERAL INFORMATION

Gene name

 RND3

Gene description

 Rho family GTPase 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA060504
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RND3 (HGNC Symbol)

Synonyms

 ARHE, Rho8, RhoE

Description

 Rho family GTPase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Chromosome

 2

Cytoband

 q23.3

Chromosome location (bp)

 150468195 - 150539011

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115963 (version 83.38)

Entrez gene

 390

UniProt

 P61587 (UniProt - Evidence at protein level)

neXtProt

 NX_P61587

Antibodypedia

 RND3 antibodies

PROTEIN BROWSER
RND3-001
RND3-002
RND3-003
RND3-004
RND3-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RND3-001
ENSP00000263895
ENST00000263895
P61587 [Direct mapping]
Rho-related GTP-binding protein RhoE
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0070062 [extracellular exosome]
Show all
 244 aa
27.4 kDa 		No 0
RND3-002
ENSP00000364886
ENST00000375734
P61587 [Direct mapping]
Rho-related GTP-binding protein RhoE
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005925 [focal adhesion]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0070062 [extracellular exosome]
Show all
 244 aa
27.4 kDa 		No 0
RND3-003
ENSP00000395997
ENST00000439275
Q53RZ3 [Direct mapping]
Putative uncharacterized protein ARHE; Rho-related GTP-binding protein RhoE
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 116 aa
13.1 kDa 		No 0
RND3-004
ENSP00000411950
ENST00000454202
Q53RZ3 [Direct mapping]
Putative uncharacterized protein ARHE; Rho-related GTP-binding protein RhoE
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 116 aa
13.1 kDa 		No 0
RND3-007
ENSP00000386576
ENST00000409557
E9PFH1 [Direct mapping]
Rho-related GTP-binding protein RhoE
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
Show all
 115 aa
12.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.