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PCYOX1

GENERAL INFORMATION

Gene name

 PCYOX1

Gene description

 Prenylcysteine oxidase 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA035193
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PCYOX1 (HGNC Symbol)

Synonyms

 KIAA0908, PCL1

Description

 Prenylcysteine oxidase 1 (HGNC Symbol)

Entrez gene summary

 Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 p13.3

Chromosome location (bp)

 70257386 - 70281191

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116005 (version 83.38)

Entrez gene

 51449

UniProt

 Q9UHG3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHG3

Antibodypedia

 PCYOX1 antibodies

PROTEIN BROWSER
PCYOX1-001
PCYOX1-002
PCYOX1-003
PCYOX1-004
PCYOX1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PCYOX1-001
ENSP00000387654
ENST00000433351
Q9UHG3 [Direct mapping]
Prenylcysteine oxidase 1
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001735 [prenylcysteine oxidase activity]
GO:0005764 [lysosome]
GO:0005774 [vacuolar membrane]
GO:0005886 [plasma membrane]
GO:0006821 [chloride transport]
GO:0008555 [chloride-transporting ATPase activity]
GO:0016670 [oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor]
GO:0030327 [prenylated protein catabolic process]
GO:0030328 [prenylcysteine catabolic process]
GO:0030329 [prenylcysteine metabolic process]
GO:0034361 [very-low-density lipoprotein particle]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1902476 [chloride transmembrane transport]
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 505 aa
56.6 kDa 		Yes 0
PCYOX1-002
ENSP00000264441
ENST00000264441
F8W8W4 [Direct mapping]
Prenylcysteine oxidase 1
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001735 [prenylcysteine oxidase activity]
GO:0005774 [vacuolar membrane]
GO:0016670 [oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor]
GO:0030328 [prenylcysteine catabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 293 aa
32.3 kDa 		Yes 0
PCYOX1-003
ENSP00000404327
ENST00000422380
C9JGT6 [Direct mapping]
Prenylcysteine oxidase 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001735 [prenylcysteine oxidase activity]
GO:0005774 [vacuolar membrane]
GO:0016670 [oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor]
GO:0030328 [prenylcysteine catabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 130 aa
14.9 kDa 		No 0
PCYOX1-004
ENSP00000408751
ENST00000451279
C9JM55 [Direct mapping]
Prenylcysteine oxidase 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001735 [prenylcysteine oxidase activity]
GO:0005774 [vacuolar membrane]
GO:0016670 [oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor]
GO:0030328 [prenylcysteine catabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 154 aa
17.7 kDa 		No 0
PCYOX1-006
ENSP00000413178
ENST00000414812
C9K055 [Direct mapping]
Prenylcysteine oxidase 1
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001735 [prenylcysteine oxidase activity]
GO:0005774 [vacuolar membrane]
GO:0016670 [oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor]
GO:0030328 [prenylcysteine catabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 209 aa
23.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.