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SUMO1

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GENERAL INFORMATION

Gene name

 SUMO1

Gene description

 Small ubiquitin-like modifier 1

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus & nuclear membrane. In addition localized to the nucleoli & nuclear bodies.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Nuclear membrane (supported)

Additional location

 In addition localized to the Nucleoli (supported), Nuclear bodies (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA056956
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus & nuclear membrane. In addition localized to the nucleoli & nuclear bodies.

Main location

 Nucleus (supported), Nuclear membrane (supported)

Additional location

 Nucleoli (supported), Nuclear bodies (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA056956 A-431 Nucleus
Nuclear membrane
Nuclear bodies
HPA056956 U-2 OS Nucleus
Nuclear membrane
Nucleoli
HPA056956 U-251 MG Nuclear membrane
Nucleoli

GENE INFORMATION

Gene name

 SUMO1 (HGNC Symbol)

Synonyms

 GMP1, OFC10, PIC1, SMT3C, SMT3H3, SUMO-1, UBL1

Description

 Small ubiquitin-like modifier 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q33.1

Chromosome location (bp)

 202206180 - 202238608

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116030 (version 83.38)

Entrez gene

 7341

UniProt

 P63165 (UniProt - Evidence at protein level)

neXtProt

 NX_P63165

Antibodypedia

 SUMO1 antibodies

PROTEIN BROWSER
SUMO1-001
SUMO1-002
SUMO1-003
SUMO1-004
SUMO1-005
SUMO1-007
SUMO1-010
SUMO1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SUMO1-001
ENSP00000376077
ENST00000392246
P63165 [Direct mapping]
Small ubiquitin-related modifier 1
A0A024R3Z2 [Target identity:100%; Query identity:100%]
Small ubiquitin-related modifier
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000792 [heterochromatin]
GO:0001650 [fibrillar center]
GO:0001741 [XY body]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008134 [transcription factor binding]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030425 [dendrite]
GO:0030578 [PML body organization]
GO:0031334 [positive regulation of protein complex assembly]
GO:0031386 [protein tag]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031647 [regulation of protein stability]
GO:0031965 [nuclear membrane]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032880 [regulation of protein localization]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044325 [ion channel binding]
GO:0044822 [poly(A) RNA binding]
GO:0045202 [synapse]
GO:0045759 [negative regulation of action potential]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0050821 [protein stabilization]
GO:0060021 [palate development]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0070911 [global genome nucleotide-excision repair]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0090204 [protein localization to nuclear pore]
GO:1901896 [positive regulation of calcium-transporting ATPase activity]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
GO:1903169 [regulation of calcium ion transmembrane transport]
Show all
 101 aa
11.6 kDa 		No 0
SUMO1-002
ENSP00000387204
ENST00000409368
B8ZZN6 [Direct mapping]
Small ubiquitin-related modifier 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0031965 [nuclear membrane]
Show all
 146 aa
16.6 kDa 		No 0
SUMO1-003
ENSP00000386472
ENST00000409498
B8ZZ67 [Direct mapping]
SMT3 suppressor of mif two 3 homolog 1 (Yeast), isoform CRA_b; Small ubiquitin-related modifier 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 62 aa
7.2 kDa 		No 0
SUMO1-004
ENSP00000386296
ENST00000409712
B9A032 [Direct mapping]
Small ubiquitin-related modifier 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0031965 [nuclear membrane]
Show all
 77 aa
8.8 kDa 		No 0
SUMO1-005
ENSP00000386753
ENST00000409181
B8ZZJ0 [Direct mapping]
Small ubiquitin-related modifier 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0031965 [nuclear membrane]
Show all
 58 aa
6.7 kDa 		No 0
SUMO1-007
ENSP00000376075
ENST00000392244
P63165 [Direct mapping]
Small ubiquitin-related modifier 1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008134 [transcription factor binding]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031334 [positive regulation of protein complex assembly]
GO:0031386 [protein tag]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031965 [nuclear membrane]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032880 [regulation of protein localization]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044325 [ion channel binding]
GO:0044822 [poly(A) RNA binding]
GO:0045759 [negative regulation of action potential]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0050821 [protein stabilization]
GO:0060021 [palate development]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0070911 [global genome nucleotide-excision repair]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
Show all
 76 aa
8.8 kDa 		No 0
SUMO1-010
ENSP00000386267
ENST00000409205
B8ZZ67 [Direct mapping]
SMT3 suppressor of mif two 3 homolog 1 (Yeast), isoform CRA_b; Small ubiquitin-related modifier 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 62 aa
7.2 kDa 		No 0
SUMO1-201
ENSP00000376076
ENST00000392245
P63165 [Direct mapping]
Small ubiquitin-related modifier 1
A0A024R3Z2 [Target identity:100%; Query identity:100%]
Small ubiquitin-related modifier
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0008076 [voltage-gated potassium channel complex]
GO:0008134 [transcription factor binding]
GO:0015459 [potassium channel regulator activity]
GO:0016032 [viral process]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0016607 [nuclear speck]
GO:0016925 [protein sumoylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031334 [positive regulation of protein complex assembly]
GO:0031386 [protein tag]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031965 [nuclear membrane]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032880 [regulation of protein localization]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044325 [ion channel binding]
GO:0044822 [poly(A) RNA binding]
GO:0045759 [negative regulation of action potential]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0050821 [protein stabilization]
GO:0060021 [palate development]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0070911 [global genome nucleotide-excision repair]
GO:1902260 [negative regulation of delayed rectifier potassium channel activity]
Show all
 101 aa
11.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.