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The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent] GO:0005537 [mannose binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030139 [endocytic vesicle] GO:0030246 [carbohydrate binding] GO:0030669 [clathrin-coated endocytic vesicle membrane] GO:0031901 [early endosome membrane] GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I] GO:0051607 [defense response to virus]
