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FARSB

GENERAL INFORMATION

Gene name

 FARSB

Gene description

 Phenylalanyl-tRNA synthetase, beta subunit

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues. Most abundant in the CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA036677 , HPA036678 , HPA061398
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FARSB (HGNC Symbol)

Synonyms

 FARSLB, FRSB, PheHB

Description

 Phenylalanyl-tRNA synthetase, beta subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Chromosome

 2

Cytoband

 q36.1

Chromosome location (bp)

 222570536 - 222656337

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116120 (version 83.38)

Entrez gene

 10056

UniProt

 Q9NSD9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NSD9

Antibodypedia

 FARSB antibodies

PROTEIN BROWSER
FARSB-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FARSB-001
ENSP00000281828
ENST00000281828
Q9NSD9 [Direct mapping]
Phenylalanine--tRNA ligase beta subunit
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0003723 [RNA binding]
GO:0004826 [phenylalanine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006432 [phenylalanyl-tRNA aminoacylation]
GO:0009328 [phenylalanine-tRNA ligase complex]
GO:0010467 [gene expression]
GO:0016020 [membrane]
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 589 aa
66.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.