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Cancer tissues displayed weak to moderate nuclear positivity. Lymphomas showed moderate cytoplasmic staining. Strong staining was observed in testicular cancers and occasional cases of melanomas, ovarian and urothelial cancers. Renal cancers were negative.
GENE INFORMATION
Gene name
PRRX1 (HGNC Symbol)
Synonyms
PHOX1, PMX1
Description
Paired related homeobox 1 (HGNC Symbol)
Entrez gene summary
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008]
P54821 [Direct mapping] Paired mesoderm homeobox protein 1
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Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P54821 [Direct mapping] Paired mesoderm homeobox protein 1
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Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0030326 [embryonic limb morphogenesis] GO:0042472 [inner ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048664 [neuron fate determination] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048844 [artery morphogenesis] GO:0051216 [cartilage development] GO:0060021 [palate development] GO:0070570 [regulation of neuron projection regeneration] GO:0071837 [HMG box domain binding] GO:0097150 [neuronal stem cell population maintenance]
G3V2N3 [Direct mapping] Paired mesoderm homeobox protein 1
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
