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The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. [provided by RefSeq, Jul 2008]
P54821 [Direct mapping] Paired mesoderm homeobox protein 1
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Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P54821 [Direct mapping] Paired mesoderm homeobox protein 1
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Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0002053 [positive regulation of mesenchymal cell proliferation] GO:0003677 [DNA binding] GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006355 [regulation of transcription, DNA-templated] GO:0030326 [embryonic limb morphogenesis] GO:0042472 [inner ear morphogenesis] GO:0042474 [middle ear morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048664 [neuron fate determination] GO:0048701 [embryonic cranial skeleton morphogenesis] GO:0048704 [embryonic skeletal system morphogenesis] GO:0048844 [artery morphogenesis] GO:0051216 [cartilage development] GO:0060021 [palate development] GO:0070570 [regulation of neuron projection regeneration] GO:0071837 [HMG box domain binding] GO:0097150 [neuronal stem cell population maintenance]
G3V2N3 [Direct mapping] Paired mesoderm homeobox protein 1
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
