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TNR

CANCER ATLAS

Gene description

 Tenascin R

Protein class

 Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA027134
HPA027150
HPA029859
CAB022343

Tissue

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Several renal cancers exhibited weak to moderate cytoplasmic and occasional membranous immunoreactivity. The remaining malignant tissues were negative.

GENE INFORMATION

Gene name

 TNR

Synonyms

Description

 Tenascin R (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013]

Chromosome

 1

Cytoband

 q25.1

Chromosome location (bp)

 175315194 - 175743770

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000116147 (version 83.38)

Entrez gene

 7143

UniProt

 Q92752 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92752

Antibodypedia

 TNR antibodies

PROTEIN BROWSER
TNR-001
TNR-002
TNR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNR-001
ENSP00000356646
ENST00000367674
Q92752 [Direct mapping]
Tenascin-R
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007155 [cell adhesion]
GO:0007158 [neuron cell-cell adhesion]
GO:0007411 [axon guidance]
GO:0008306 [associative learning]
GO:0009986 [cell surface]
GO:0010977 [negative regulation of neuron projection development]
GO:0022029 [telencephalon cell migration]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030198 [extracellular matrix organization]
GO:0030517 [negative regulation of axon extension]
GO:0035641 [locomotory exploration behavior]
GO:0045121 [membrane raft]
GO:0048692 [negative regulation of axon extension involved in regeneration]
GO:0050804 [modulation of synaptic transmission]
GO:0050805 [negative regulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050885 [neuromuscular process controlling balance]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0051971 [positive regulation of transmission of nerve impulse]
GO:0060291 [long-term synaptic potentiation]
GO:0072534 [perineuronal net]
Show all
 1358 aa
149.6 kDa 		Yes 0
TNR-002
ENSP00000403413
ENST00000422274
H0Y668 [Direct mapping]
Tenascin-R
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 181 aa
19.8 kDa 		No 0
TNR-201
ENSP00000263525
ENST00000263525
Q92752 [Direct mapping]
Tenascin-R
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007155 [cell adhesion]
GO:0007411 [axon guidance]
GO:0030198 [extracellular matrix organization]
Show all
 1358 aa
149.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.