Cell atlas - FAM20B - The Human Protein Atlas

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FAM20B

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleoplasm

Human cell
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FAM20B
Gene description	Family with sequence similarity 20, member B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)
Additional location	In addition localized to the Nucleoplasm (uncertain)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA007409
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the nucleoplasm.

Main location

Golgi apparatus (supported)

Additional location

Nucleoplasm (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA007409	SH-SY5Y	Nucleoplasm
	HPA007409	SH-SY5Y	Golgi apparatus
	HPA007409	U-2 OS	Nucleoplasm
	HPA007409	U-2 OS	Golgi apparatus
	HPA007409	U-251 MG	Golgi apparatus

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA007409	U-2 OS	Image	Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. FAM20B localizes to the Golgi apparatus, but not to the cis-Golgi compartment.

GENE INFORMATION
Gene name	FAM20B (HGNC Symbol)
Synonyms	GXK1, KIAA0475
Description	Family with sequence similarity 20, member B (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q25.2
Chromosome location (bp)	179025804 - 179076562
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000116199 (version 83.38)
Entrez gene	9917
UniProt	O75063 (UniProt - Evidence at protein level)
neXtProt	NX_O75063
Antibodypedia	FAM20B antibodies

PROTEIN BROWSER

FAM20B-001	FAM20B-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM20B-001 ENSP00000263733 ENST00000263733	O75063 [Direct mapping] Glycosaminoglycan xylosylkinase A0A024R918 [Target identity:100%; Query identity:100%] Family with sequence similarity 20, member B, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0016021 [integral component of membrane] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0046872 [metal ion binding] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	409 aa 46.4 kDa	No	0
FAM20B-002 ENSP00000404005 ENST00000440702	X6RH03 [Direct mapping] Glycosaminoglycan xylosylkinase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		138 aa 15.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.